Favro's work deals with the nature of perception, reality, and art itself, as well as with the insistent presence of the machine environment. He is an important figure among a significant generation of artists – Jack Chambers, Greg Curnoe and Ron Martin among them – who became active in that city in the early 1960s and drew national attention as the London Regionalism|London Regionalist School of artists. He is also well known as a founding member of the Nihilist Spasm Band.